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-synuclein, that is a principal element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK 2 in 1998, that's an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) worry, suggest that dysfunction from the intracellular proteinase methods, such as ubiquitin-proteasome process or lysosomal procedure, which eliminates needless harmful prot
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